The p53 protein is a mediator of the cellular response to DNA damage. The aim of this study was to evaluate the predictive and/or prognostic value of p53 expression in relation to the molecular subtypes of breast cancer in patients treated with preoperative chemotherapy.
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Data di pubblicazione: | 2010 | |
Titolo: | Predictive and prognostic role of p53 according to tumor phenotype in breast cancer patients treated with preoperative chemotherapy: a single-institution analysis | |
Autori: | Guarneri, Valentina; Barbieri, Elena; Piacentini, Federico; Giovannelli, Simona; Ficarra, Guido; Frassoldati, Antonio; Maiorana, Antonino; D'Amico, Roberto; Conte, Pierfranco | |
Rivista: | THE INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | |
Parole Chiave: | Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Female; Humans; Mastectomy, Segmental; Middle Aged; Phenotype; Predictive Value of Tests; Preoperative Period; Prognosis; Remission Induction; Survival Analysis; Treatment Outcome; Tumor Suppressor Protein p53 | |
Abstract: | The p53 protein is a mediator of the cellular response to DNA damage. The aim of this study was to evaluate the predictive and/or prognostic value of p53 expression in relation to the molecular subtypes of breast cancer in patients treated with preoperative chemotherapy. | |
Handle: | http://hdl.handle.net/11392/2377829 | |
Appare nelle tipologie: | 03.1 Articolo su rivista |
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