Predictive and prognostic role of p53 according to tumor phenotype in breast cancer patients treated with preoperative chemotherapy: a single-institution analysis

The p53 protein is a mediator of the cellular response to DNA damage. The aim of this study was to evaluate the predictive and/or prognostic value of p53 expression in relation to the molecular subtypes of breast cancer in patients treated with preoperative chemotherapy.

Data di pubblicazione: 2010
Titolo: Predictive and prognostic role of p53 according to tumor phenotype in breast cancer patients treated with preoperative chemotherapy: a single-institution analysis
Autori: Guarneri, Valentina; Barbieri, Elena; Piacentini, Federico; Giovannelli, Simona; Ficarra, Guido; Frassoldati, Antonio; Maiorana, Antonino; D'Amico, Roberto; Conte, Pierfranco
Rivista: THE INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
Parole Chiave: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Female; Humans; Mastectomy, Segmental; Middle Aged; Phenotype; Predictive Value of Tests; Preoperative Period; Prognosis; Remission Induction; Survival Analysis; Treatment Outcome; Tumor Suppressor Protein p53
Abstract: The p53 protein is a mediator of the cellular response to DNA damage. The aim of this study was to evaluate the predictive and/or prognostic value of p53 expression in relation to the molecular subtypes of breast cancer in patients treated with preoperative chemotherapy.
Handle: http://hdl.handle.net/11392/2377829
Appare nelle tipologie:03.1 Articolo su rivista

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