Radiochemical purity and stability of 99mTc-HMPAO in routine preparations

The aim of this work was to investigate the influence of pH, recovery volume, type of saline solution plastic or glass container, used to prepare the technetium-99m-d,l-hexamethylpropyleneamineoxime ([Tc-99m]Tc-d,l-HMPAO] radiopharmaceutical starting from generator produced sodium pertechnetate in nuclear medicine routine preparations. We observed that, neither the container type, nor the pH of 0.9% NaCl, used for diluting the [Tc-99m]pertechnetate, influenced [Tc-99m]Tc-d,l-HMPAO radiochemical purity (RCP) and stability, that decreased proportionally with the final volume of the preparation. In particular, the RCP of 1 mL kits preparations, at 30 min was found to be less than 80%.