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EnglishThe aim of this work was to investigate the influence of pH, recovery volume, type of saline solution plastic or glass container, used to prepare the technetium-99m-d,l-hexamethylpropyleneamineoxime ([99mTc]Tc-d,l-HMPAO] radiopharmaceutical starting from generator produced sodium pertechnetate in nuclear medicine routine preparations. We observed that, neither the container type, nor the pH of 0.9% NaCl, used for diluting the [99mTc]pertechnetate, influenced [99mTc]Tc-d,l-HMPAO radiochemical purity (RCP) and stability, that decreased proportionally with the final volume of the preparation. In particular, the RCP of 1 mL kits preparations, at 30 min was found to be less than 80%.
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| Data di pubblicazione: | 2017 | |
| Titolo: | Radiochemical purity and stability of 99mTc-HMPAO in routine preparations | |
| Autori: | Uccelli, Licia; Martini, Petra; Pasquali, Micol; Boschi, Alessandra | |
| Rivista: | JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | |
| Abstract in inglese: | The aim of this work was to investigate the influence of pH, recovery volume, type of saline solution plastic or glass container, used to prepare the technetium-99m-d,l-hexamethylpropyleneamineoxime ([99mTc]Tc-d,l-HMPAO] radiopharmaceutical starting from generator produced sodium pertechnetate in nuclear medicine routine preparations. We observed that, neither the container type, nor the pH of 0.9% NaCl, used for diluting the [99mTc]pertechnetate, influenced [99mTc]Tc-d,l-HMPAO radiochemical purity (RCP) and stability, that decreased proportionally with the final volume of the preparation. In particular, the RCP of 1 mL kits preparations, at 30 min was found to be less than 80%. | |
| Handle: | http://hdl.handle.net/11392/2377398 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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