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EnglishIntestinal pseudo-obstruction is more commonly known in its chronic form (CIPO), a cluster of rare diseases characterized by gastrointestinal muscle and nerve impairment, so severe to result in a markedly compromised peristalsis mimicking an intestinal occlusion. The management of CIPO requires the cooperation of a group of specialists: the disease has to be confirmed by a number of tests to avoid mistakes in the differential diagnosis. The treatment should be aimed at relieving symptoms arising from gut dysmotility (ideally using prokinetic agents), controlling abdominal pain (possibly with non-opioid antinociceptive drugs) and optimizing nutritional support. Furthermore, a thorough diagnostic work-up is mandatory to avoid unnecessary (potentially harmful) surgery and to select patients with clear indication to intestinal or multivisceral transplantation.
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| Data di pubblicazione: | 2015 | |
| Titolo: | Advancement in the clinical management of intestinal pseudo-obstruction | |
| Autori: | Lauro A.; De Giorgio R.; Pinna A.D. | |
| Rivista: | EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | |
| Parole Chiave: | chronic intestinal pseudo-obstruction; enteral nutrition; intestinal diseases; intestinal motility; jejunostomy; manometry; parenteral nutrition; prokinetics; transplantation; Analgesics; Anti-Bacterial Agents; Antiemetics; Diagnosis; Differential; Humans; Intestinal Pseudo-Obstruction; Parenteral Nutrition; Treatment Outcome; Disease Management | |
| Abstract in inglese: | Intestinal pseudo-obstruction is more commonly known in its chronic form (CIPO), a cluster of rare diseases characterized by gastrointestinal muscle and nerve impairment, so severe to result in a markedly compromised peristalsis mimicking an intestinal occlusion. The management of CIPO requires the cooperation of a group of specialists: the disease has to be confirmed by a number of tests to avoid mistakes in the differential diagnosis. The treatment should be aimed at relieving symptoms arising from gut dysmotility (ideally using prokinetic agents), controlling abdominal pain (possibly with non-opioid antinociceptive drugs) and optimizing nutritional support. Furthermore, a thorough diagnostic work-up is mandatory to avoid unnecessary (potentially harmful) surgery and to select patients with clear indication to intestinal or multivisceral transplantation. | |
| Digital Object Identifier (DOI): | 10.1586/17474124.2014.940317 | |
| Handle: | http://hdl.handle.net/11392/2375083 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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