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EnglishIn a model of abdominal surgery, which consisted of cecal manipulation and induces postoperative ileus in rats, we studied c-fos protein expression in the nucleus of the solitary tract (NTS), the spinal cord and dorsal root ganglia. Abdominal surgery resulted in a significantly higher number of c-fos protein immunoreactive cells in the NTS compared with controls but not in dorsal root ganglia and resulted in only a few scattered cells in the spinal cord. Neurons expressing c-fos protein were concentrated in NTS regions where cecal afferents terminate. These findings support the hypothesis that sensory vagal pathways partly mediate abdominal surgery-induced postoperative ileus.
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| Data di pubblicazione: | 1993 | |
| Titolo: | Abdominal surgery induces c-fos expression in the nucleus of the solitary tract in the rat | |
| Autori: | Zittel, Tt; DE GIORGIO, Roberto; Brecha, Nc; Sternini, C; Raybould, H. E. | |
| Rivista: | NEUROSCIENCE LETTERS | |
| Abstract in inglese: | In a model of abdominal surgery, which consisted of cecal manipulation and induces postoperative ileus in rats, we studied c-fos protein expression in the nucleus of the solitary tract (NTS), the spinal cord and dorsal root ganglia. Abdominal surgery resulted in a significantly higher number of c-fos protein immunoreactive cells in the NTS compared with controls but not in dorsal root ganglia and resulted in only a few scattered cells in the spinal cord. Neurons expressing c-fos protein were concentrated in NTS regions where cecal afferents terminate. These findings support the hypothesis that sensory vagal pathways partly mediate abdominal surgery-induced postoperative ileus. | |
| Digital Object Identifier (DOI): | 10.1016/0304-3940(93)90803-S | |
| Handle: | http://hdl.handle.net/11392/2374989 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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