In a model of abdominal surgery, which consisted of cecal manipulation and induces postoperative ileus in rats, we studied c-fos protein expression in the nucleus of the solitary tract (NTS), the spinal cord and dorsal root ganglia. Abdominal surgery resulted in a significantly higher number of c-fos protein immunoreactive cells in the NTS compared with controls but not in dorsal root ganglia and resulted in only a few scattered cells in the spinal cord. Neurons expressing c-fos protein were concentrated in NTS regions where cecal afferents terminate. These findings support the hypothesis that sensory vagal pathways partly mediate abdominal surgery-induced postoperative ileus.

Abdominal surgery induces c-fos expression in the nucleus of the solitary tract in the rat

DE GIORGIO, Roberto;
1993

Abstract

In a model of abdominal surgery, which consisted of cecal manipulation and induces postoperative ileus in rats, we studied c-fos protein expression in the nucleus of the solitary tract (NTS), the spinal cord and dorsal root ganglia. Abdominal surgery resulted in a significantly higher number of c-fos protein immunoreactive cells in the NTS compared with controls but not in dorsal root ganglia and resulted in only a few scattered cells in the spinal cord. Neurons expressing c-fos protein were concentrated in NTS regions where cecal afferents terminate. These findings support the hypothesis that sensory vagal pathways partly mediate abdominal surgery-induced postoperative ileus.
Zittel, Tt; DE GIORGIO, Roberto; Brecha, Nc; Sternini, C; Raybould, H. E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2374989
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