Mediators released by the intestinal mucosa of patients with irritable bowel syndrome (IBS) affect the function of enteric and extrinsic sensory nerves, which can contribute to the development of symptoms. Little is known about the effects of mucosal mediators on intestinal neuroplasticity. We investigated how these mediators affect the phenotypes of colonic mucosa nerve fibers, neuron differentiation, and fiber outgrowth.

Nerve fiber outgrowth is increased in the intestinal mucosa of patients with irritable bowel syndrome

DE GIORGIO, Roberto;
2015

Abstract

Mediators released by the intestinal mucosa of patients with irritable bowel syndrome (IBS) affect the function of enteric and extrinsic sensory nerves, which can contribute to the development of symptoms. Little is known about the effects of mucosal mediators on intestinal neuroplasticity. We investigated how these mediators affect the phenotypes of colonic mucosa nerve fibers, neuron differentiation, and fiber outgrowth.
Dothel, Giovanni; Barbaro Maria, Raffaella; Boudin, Hélène; Vasina, Valentina; Cremon, Cesare; Gargano, Luciana; Bellacosa, Lara; DE GIORGIO, Roberto; Le Berre Scoul, Catherine; Aubert, Philippe; Neunlist, Michel; De Ponti, Fabrizio; Stanghellini, Vincenzo; Barbara, Giovanni
File in questo prodotto:
File Dimensione Formato  
PIIS0016508515001602.pdf

solo gestori archivio

Descrizione: Full text ed
Tipologia: Full text (versione editoriale)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 2.49 MB
Formato Adobe PDF
2.49 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
dothel2015.pdf

accesso aperto

Descrizione: AAM - post print
Tipologia: Post-print
Licenza: Creative commons
Dimensione 2.01 MB
Formato Adobe PDF
2.01 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2374949
Citazioni
  • ???jsp.display-item.citation.pmc??? 52
  • Scopus 112
  • ???jsp.display-item.citation.isi??? 102
social impact