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EnglishMediators released by the intestinal mucosa of patients with irritable bowel syndrome (IBS) affect the function of enteric and extrinsic sensory nerves, which can contribute to the development of symptoms. Little is known about the effects of mucosal mediators on intestinal neuroplasticity. We investigated how these mediators affect the phenotypes of colonic mucosa nerve fibers, neuron differentiation, and fiber outgrowth.
| Data di pubblicazione: | 2015 | |
| Titolo: | Nerve fiber outgrowth is increased in the intestinal mucosa of patients with irritable bowel syndrome | |
| Autori: | Dothel, Giovanni; Barbaro Maria, Raffaella; Boudin, Hélène; Vasina, Valentina; Cremon, Cesare; Gargano, Luciana; Bellacosa, Lara; De Giorgio, Roberto; Le Berre Scoul, Catherine; Aubert, Philippe; Neunlist, Michel; De Ponti, Fabrizio; Stanghellini, Vincenzo; Barbara, Giovanni | |
| Rivista: | GASTROENTEROLOGY | |
| Keywords: | Enteric Nerves; Growth-Associated Protein 43; Mast Cells; Nerve Growth Factor; Adult; Aged; Animals; Biomarkers; Biopsy; Case-Control Studies; Cell Line; Tumor; Colon; Enteric Nervous System; Female; GAP-43 Protein; Humans; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Middle Aged; Neuritis; Phosphopyruvate Hydratase; Rats; Receptor; trkA; Young Adult; Neurogenesis | |
| Abstract in inglese: | Mediators released by the intestinal mucosa of patients with irritable bowel syndrome (IBS) affect the function of enteric and extrinsic sensory nerves, which can contribute to the development of symptoms. Little is known about the effects of mucosal mediators on intestinal neuroplasticity. We investigated how these mediators affect the phenotypes of colonic mucosa nerve fibers, neuron differentiation, and fiber outgrowth. | |
| Digital Object Identifier (DOI): | 10.1053/j.gastro.2015.01.042 | |
| Handle: | http://hdl.handle.net/11392/2374949 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| PIIS0016508515001602.pdf | Full text ed | Full text (versione editoriale) | NON PUBBLICO - Accesso privato/ristretto | Administrator Richiedi una copia |
| dothel2015.pdf | AAM - post print | Post-print |  | Open Access Visualizza/Apri |
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