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EnglishIn this review, we address the possible role of the essential amino acid L-tryptophan or its metabolic derivative 5-hydroxytryptophan in the modulation of serotonin (5-hydroxytryptamine) synthesis and thereby in affecting the pathophysiology of central and peripheral nervous system disorders, including depression and irritable bowel syndrome. L-Tryptophan may represent a link between apparently disparate functional disorders and is of interest for general gastroenterologists, neurogastroenterologists, and neurologists. On the basis of estimates showing that approximately 20% of patients with functional bowel disorders seeking care in referral centres have psychiatric comorbidity, we attempt to provide a conceptual framework for defining the possible role of L-tryptophan in this population
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| Data di pubblicazione: | 2003 | |
| Titolo: | Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders | |
| Autori: | Agazzi, A; De Ponti, F; DE GIORGIO, Roberto; Candura, Sm; Anselmi, L; Cervio, E; Di Nucci, A; Tonini, M. | |
| Rivista: | DIGESTIVE AND LIVER DISEASE | |
| Abstract in inglese: | In this review, we address the possible role of the essential amino acid L-tryptophan or its metabolic derivative 5-hydroxytryptophan in the modulation of serotonin (5-hydroxytryptamine) synthesis and thereby in affecting the pathophysiology of central and peripheral nervous system disorders, including depression and irritable bowel syndrome. L-Tryptophan may represent a link between apparently disparate functional disorders and is of interest for general gastroenterologists, neurogastroenterologists, and neurologists. On the basis of estimates showing that approximately 20% of patients with functional bowel disorders seeking care in referral centres have psychiatric comorbidity, we attempt to provide a conceptual framework for defining the possible role of L-tryptophan in this population | |
| Digital Object Identifier (DOI): | 10.1016/S1590-8658(03)00277-9 | |
| Handle: | http://hdl.handle.net/11392/2374891 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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