Reaction of hydrated copper(ii) ibuprofenate with various nitrogen donor ligands, β-picoline, γ-picoline, pyrrolidine and unsymetrical dimethyl ethylenediamine (unsym-dmen), at room temperature in a methanol:water mixture (4:1 v/v) yielded four new complexes, [Cu(Ibu)2(β-picoline)2(H2O)], 1; [Cu(Ibu)2(γ-picoline)2(H2O)]·H2O, 2; [Cu(Ibu)2(pyrrolidine)2]·H2O, 3; and [Cu(unsym-dmen)2(H2O)](Ibu)2, 4, respectively, where Ibu = deprotonated Ibuprofen (HIbu). The newly synthesized complexes have been characterized by elemental analyses, spectroscopic methods (FT-IR, UV-Vis and EPR), TGA and single crystal X-ray structure determination. Crystallographic investigations revealed that all the complexes are monomeric in nature, in contrast to the dimeric nature of copper(ii) ibuprofenate solvates. EPR studies clearly revealed that the chromophore present in all complexes (1-4) is consistent with the structures determined by X-ray crystallography. The cytotoxic effects of all complexes were tested by a colorimetric assay on three human cell lines; though the activity was affected by the nature of the cell line, the newly synthesized complexes 1-4 showed higher cytotoxicity than the parent molecule against all the tumoral cell lines.

Four monomeric copper(II) complexes of non-steroidal anti-inflammatory drug Ibuprofen and N-donor ligands: Syntheses, characterization, crystal structures and cytotoxicity studies

TENTI, Lorenzo;FERRETTI, Valeria;
2017

Abstract

Reaction of hydrated copper(ii) ibuprofenate with various nitrogen donor ligands, β-picoline, γ-picoline, pyrrolidine and unsymetrical dimethyl ethylenediamine (unsym-dmen), at room temperature in a methanol:water mixture (4:1 v/v) yielded four new complexes, [Cu(Ibu)2(β-picoline)2(H2O)], 1; [Cu(Ibu)2(γ-picoline)2(H2O)]·H2O, 2; [Cu(Ibu)2(pyrrolidine)2]·H2O, 3; and [Cu(unsym-dmen)2(H2O)](Ibu)2, 4, respectively, where Ibu = deprotonated Ibuprofen (HIbu). The newly synthesized complexes have been characterized by elemental analyses, spectroscopic methods (FT-IR, UV-Vis and EPR), TGA and single crystal X-ray structure determination. Crystallographic investigations revealed that all the complexes are monomeric in nature, in contrast to the dimeric nature of copper(ii) ibuprofenate solvates. EPR studies clearly revealed that the chromophore present in all complexes (1-4) is consistent with the structures determined by X-ray crystallography. The cytotoxic effects of all complexes were tested by a colorimetric assay on three human cell lines; though the activity was affected by the nature of the cell line, the newly synthesized complexes 1-4 showed higher cytotoxicity than the parent molecule against all the tumoral cell lines.
Kumar, Santosh; Garg, Shipra; Sharma, Raj Pal; Venugopalan, Paloth; Tenti, Lorenzo; Ferretti, Valeria; Nivelle, Laetitia; Tarpin, Michel; Guillon, Emmanuel
File in questo prodotto:
File Dimensione Formato  
11392-2374003_fulltext_Ferretti_Valeria.pdf

solo gestori archivio

Descrizione: versione editoriale
Tipologia: Full text (versione editoriale)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 3.43 MB
Formato Adobe PDF
3.43 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
11392-2374003_postprint_Ferretti_Valeria.pdf

accesso aperto

Descrizione: post print
Tipologia: Post-print
Licenza: Creative commons
Dimensione 1.93 MB
Formato Adobe PDF
1.93 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2374003
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 19
social impact