Monoolein Aqueous Dispersions as a delivery system for quercetin

This study describes the preparation, characterization and in vitro release of monoolein aqueous dispersions (MAD) encapsulating quercetin (QT). As emulsifier, sodium cholate was employed at two different concentrations, namely 0.15% and 0.25% with respect to the total weight of the formulation. Cryogenic Transmission electron microscopy and X-ray analysis indicated that MAD015 are a mixture of vesicles and cubic structures, whilst MAD025 are mainly characterized by unilamellar vesicular structures. Photon correlation spectroscopy (PCS) and Sedimentation Field Flow Fractionation (SdFFF) showed a MAD size higher than 300 nm that over 100 days from analysis reduces up to 200 nm. In vitro Franz cell experiments showed that the two systems had a similar behaviour in the release of QT. Experiments on antioxidant activity of MAD containing QT demonstrated that their activity parallel with the content of encapsulated QT within the MAD formulations produced. Taken together these results allow us to conclude that MAD can be potentially proposed for the delivery of QT.