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EnglishBilateral striatal necrosis (BSN) is relatively rare and has been related to a wide array of causes, including nuclear and mitochondrial DNA mutations. We report the clinical vignette of a patient with a 37 years-history of generalized dystonia secondary to BSN associated with multiple mitochondrial DNA deletions of undefined origin. Globus pallidus interna deep brain stimulation produced sustained benefit, with predominant improvements in disability. © 2007 Movement Disorder Society.
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| Data di pubblicazione: | 2008 | |
| Titolo: | Bilateral striatal necrosis, dystonia and multiple mitochondrial DNA deletions: Case study and effect of deep brain stimulation | |
| Autori: | Aniello, Maria Stella; Martino, Davide; Petruzzella, Vittoria; Eleopra, Roberto; Mancuso, Michelangelo; Dell'Aglio, Rosa; Cavallo, Michele; Siciliano, Gabriele; Defazio, Giovanni | |
| Rivista: | MOVEMENT DISORDERS | |
| Parole Chiave: | Bilateral striatal necrosis; Deep brain stimulation; Dystonia; Mitochondrial DNA; Adult; Corpus Striatum; DNA, Mitochondrial; Deep Brain Stimulation; Disease Progression; Dystonia; Functional Laterality; Humans; Magnetic Resonance Imaging; Male; Mitochondrial Diseases; Necrosis; Treatment Outcome; Gene Deletion; Neurology (clinical); Neuroscience (all) | |
| Abstract in inglese: | Bilateral striatal necrosis (BSN) is relatively rare and has been related to a wide array of causes, including nuclear and mitochondrial DNA mutations. We report the clinical vignette of a patient with a 37 years-history of generalized dystonia secondary to BSN associated with multiple mitochondrial DNA deletions of undefined origin. Globus pallidus interna deep brain stimulation produced sustained benefit, with predominant improvements in disability. © 2007 Movement Disorder Society. | |
| Digital Object Identifier (DOI): | 10.1002/mds.21760 | |
| Handle: | http://hdl.handle.net/11392/2373665 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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