Clinical diagnosis of AD remains a challenge since there are no validated tests for an affirmative diagnosis and moreover several conditions can mimic it and their accuracy is suboptimal. Positron Emission Tomography (PET), is a modality for early detection of AD. 18F-Florbetapir is a novel PET tracer for amyloid brain pathology and AD imaging, while PET images with 18F-fluorodeoxyglucose (FDG) for cerebral glucose metabolism can provide complementary information to amyloid plaque imaging for diagnosis of AD. Aim of our study was to evaluate: (a) to witch degree amyloid imaging data could alter our clinical and diagnostic approach to AD, (b) the concordance degree with FDG PET imaging.

18F-Florbetapir and 18F-FDG PET studies in the diagnostic evaluation of Alzheimer's disease

GRAGNANIELLO, Daniela;CITTANTI, Corrado;MILANI, Paola;TUGNOLI, Valeria
2016

Abstract

Clinical diagnosis of AD remains a challenge since there are no validated tests for an affirmative diagnosis and moreover several conditions can mimic it and their accuracy is suboptimal. Positron Emission Tomography (PET), is a modality for early detection of AD. 18F-Florbetapir is a novel PET tracer for amyloid brain pathology and AD imaging, while PET images with 18F-fluorodeoxyglucose (FDG) for cerebral glucose metabolism can provide complementary information to amyloid plaque imaging for diagnosis of AD. Aim of our study was to evaluate: (a) to witch degree amyloid imaging data could alter our clinical and diagnostic approach to AD, (b) the concordance degree with FDG PET imaging.
PET, Florbetapir, FDG, Alzheimer
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/2372977
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