Aim. In the Mediterranean countries, several described medicinal plants are derived from Lebanon. According to Tohme et al. there are 2597 species in Lebanon. More than fifty two percent are endemic to Lebanon. In this paper we show that the ethanol fraction of the stem of Berberis libanotica is able to inhibit the viability of HTLV-1 positive (HuT-102) and HTLV-1 negative (CEM) cell lines of malignant T-cell leukemia. Methods. After traditional maceration to extract the ethanol fraction from Berberis libanotica stem, the in vitro viability was assayed. Results. The results suggest that Berberis libanotica (a Lebanese medicinal plant) contains a substantial amount of secondary metabolites such as alkaloids powerful in inhibiting the viability of HuT-102 and CEM cell lines. Conclusion. The obtained results demonstrate a novel anticancer property of Berberis libanotica stem extracts, in addition to the previously reported anti-inflammatory activity.

The ethanol fraction from the stem of Berberis libanotica inhibits the viability of adult T cell leukemia

LAMPRONTI, Ilaria
2012

Abstract

Aim. In the Mediterranean countries, several described medicinal plants are derived from Lebanon. According to Tohme et al. there are 2597 species in Lebanon. More than fifty two percent are endemic to Lebanon. In this paper we show that the ethanol fraction of the stem of Berberis libanotica is able to inhibit the viability of HTLV-1 positive (HuT-102) and HTLV-1 negative (CEM) cell lines of malignant T-cell leukemia. Methods. After traditional maceration to extract the ethanol fraction from Berberis libanotica stem, the in vitro viability was assayed. Results. The results suggest that Berberis libanotica (a Lebanese medicinal plant) contains a substantial amount of secondary metabolites such as alkaloids powerful in inhibiting the viability of HuT-102 and CEM cell lines. Conclusion. The obtained results demonstrate a novel anticancer property of Berberis libanotica stem extracts, in addition to the previously reported anti-inflammatory activity.
Lampronti, Ilaria
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/2372705
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 10
social impact