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EnglishDrug-induced liver injury (DILI) is the most common drug adverse event. Although DILI in paediatric age is relatively rare, it accounts for 20% of acute liver failure. Pathogenetic mechanisms are mostly idiosyncratic and therefore unpredictable and they mimic all forms of acute and chronic hepatobiliary diseases. Diagnosis can be difficult and a high degree of suspicion should be maintained. The most common drugs leading to DILI are acetaminophen, with a dose-dependent liver toxicity, anti-tuberculosis drugs, central nervous system agents, and anti-neoplastic drugs. Recently synthetic psychoactive drugs (Ecstasy) and herbal and dietary supplements have an increasing role in adolescent DILI.
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| Data di pubblicazione: | 2012 | |
| Titolo: | Il danno epatico da farmaci nel bambino | |
| Autori: | Maggiore, Giuseppe; Nastasio, Silvia; Cirillo, Francesco; Sciveres, Marco | |
| Rivista: | MEDICO E BAMBINO | |
| Parole Chiave: | Danno epatico da farmaci, insufficienza epatica acuta | |
| Abstract: | Drug-induced liver injury (DILI) is the most common drug adverse event. Although DILI in paediatric age is relatively rare, it accounts for 20% of acute liver failure. Pathogenetic mechanisms are mostly idiosyncratic and therefore unpredictable and they mimic all forms of acute and chronic hepatobiliary diseases. Diagnosis can be difficult and a high degree of suspicion should be maintained. The most common drugs leading to DILI are acetaminophen, with a dose-dependent liver toxicity, anti-tuberculosis drugs, central nervous system agents, and anti-neoplastic drugs. Recently synthetic psychoactive drugs (Ecstasy) and herbal and dietary supplements have an increasing role in adolescent DILI. | |
| Handle: | http://hdl.handle.net/11392/2370498 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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