Titanium is the gold standard material to produce dental implants from more than 30 years, showing high success rate in different clinical scenarios. Zirconia implants were recently introduced to overwhelm some aesthetic and biological problems that can arise from titanium. Preclinical studies show that, from a mechanical point of view, zirconia may be a suitable substitute for titanium in implant fabrication. Three-dimensional finite element analysis (FEA) models found no difference between titanium and titanium- zirconium alloy implants, neither for early nor conventional functional loading. Nevertheless, zirconia presents the same osseoconductive properties of the titanium, even if the few clinical studies show survival and success rates slightly inferior for zirconia implants comparing to titanium ones, and long-term follow-ups are missing. For these reasons, the majority of authors agree to be cautious for proposing zirconia implants as widespread substitute of titanium implants.