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EnglishThe diagnosis of Gliomatosis cerebri (GC) is known to be difficult and is still a matter of debate. We describe an in vivo case of GC associated with a pituitary tumor. A 47-year-old woman presented with short-term memory loss. A MRI revealed the presence of a pituitary enhancing tumor and a diffuse lesion involving the brain. A left pterional craniotomy with partial temporal lobectomy and removal of the pituitary lesion were performed in order to obtain diagnosis. The histological analyses showed a pituitary non-functioning tumor and a GC consisting of neoplastic oligodendrocytes and astrocytes. Both lesions showed nuclear immunoreactivity for progesterone receptors (PGr) and estrogen receptors (EGr). This result could suggest there is a common receptor substrate in these tumors. In this case hormones could constitute a common step in tumorigenesis of both lesions.
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| Data di pubblicazione: | 2005 | |
| Titolo: | Gliomatosis cerebri and pituitary adenoma: case report and literature review | |
| Autori: | Mangiola, A; De Bonis, P; Guerriero, M; Pompucci, A; Anile, C | |
| Rivista: | JOURNAL OF NEURO-ONCOLOGY | |
| Parole Chiave: | Adenoma; Brain Neoplasms; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Neoplasms, Multiple Primary; Neoplasms, Neuroepithelial; Pituitary Neoplasms; Receptors, Estrogen; Receptors, Progesterone; Tomography, X-Ray Computed | |
| Abstract: | The diagnosis of Gliomatosis cerebri (GC) is known to be difficult and is still a matter of debate. We describe an in vivo case of GC associated with a pituitary tumor. A 47-year-old woman presented with short-term memory loss. A MRI revealed the presence of a pituitary enhancing tumor and a diffuse lesion involving the brain. A left pterional craniotomy with partial temporal lobectomy and removal of the pituitary lesion were performed in order to obtain diagnosis. The histological analyses showed a pituitary non-functioning tumor and a GC consisting of neoplastic oligodendrocytes and astrocytes. Both lesions showed nuclear immunoreactivity for progesterone receptors (PGr) and estrogen receptors (EGr). This result could suggest there is a common receptor substrate in these tumors. In this case hormones could constitute a common step in tumorigenesis of both lesions. | |
| Digital Object Identifier (DOI): | 10.1007/s11060-004-7901-3 | |
| Handle: | http://hdl.handle.net/11392/2368692 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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