In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other skin diseases such as early photo-aging. Among solar radiation, ultraviolet (UV) is mainly responsible for inducing skin problems. In search of novel photoprotective purines, a new series of 8-substituted purines were synthesized from commercially available 6-hydroxy-4,5-diaminopyrimidine hemisulfate or 4,5-diaminopyrimidine. All the title compounds were investigated for their UV-filter, antioxidant, antifugal and antiproliferative activities. For the photoprotective assays we used a diffuse transmittance technique to determine the SPF in vitro, and DPPH and FRAP tests for antioxidant activity evaluation of the more potent compounds. Compound 26 proved, among the others, to be a good radical-scavenger and was also endowed with broad-spectrum UVA filtering capabilities, suitable to be developed as a protective molecule.

A multitarget approach toward the development of a novel series of 8-substituted purines for photoprotection and prevention of ultra violet (UV) related damages

Bino, Alessia;BENETTI, Simonetta;MANFREDINI, Stefano;VERTUANI, Silvia
Penultimo
;
BALDISSEROTTO, Anna
Ultimo
2017

Abstract

In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other skin diseases such as early photo-aging. Among solar radiation, ultraviolet (UV) is mainly responsible for inducing skin problems. In search of novel photoprotective purines, a new series of 8-substituted purines were synthesized from commercially available 6-hydroxy-4,5-diaminopyrimidine hemisulfate or 4,5-diaminopyrimidine. All the title compounds were investigated for their UV-filter, antioxidant, antifugal and antiproliferative activities. For the photoprotective assays we used a diffuse transmittance technique to determine the SPF in vitro, and DPPH and FRAP tests for antioxidant activity evaluation of the more potent compounds. Compound 26 proved, among the others, to be a good radical-scavenger and was also endowed with broad-spectrum UVA filtering capabilities, suitable to be developed as a protective molecule.
Djuidje, ERNESTINE NICAISE; Dissette, Valeria; Bino, Alessia; Benetti, Simonetta; Balzarini, Jan; Liekens, Sandra; Manfredini, Stefano; Vertuani, Silvia; Baldisserotto, Anna
File in questo prodotto:
File Dimensione Formato  
Manuscript pre print.pdf

accesso aperto

Descrizione: versione preprint
Tipologia: Pre-print
Licenza: PUBBLICO - Pubblico con Copyright
Dimensione 454.4 kB
Formato Adobe PDF
454.4 kB Adobe PDF Visualizza/Apri
Editoriale11392_2368271.pdf

solo gestori archivio

Descrizione: versione editoriale
Tipologia: Full text (versione editoriale)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 513.3 kB
Formato Adobe PDF
513.3 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/2368271
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact