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EnglishIn environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other skin diseases such as early photo-aging. Among solar radiation, ultraviolet (UV) is mainly responsible for inducing skin problems. In search of novel photoprotective purines, a new series of 8-substituted purines were synthesized from commercially available 6-hydroxy-4,5-diaminopyrimidine hemisulfate or 4,5-diaminopyrimidine. All the title compounds were investigated for their UV-filter, antioxidant, antifugal and antiproliferative activities. For the photoprotective assays we used a diffuse transmittance technique to determine the SPF in vitro, and DPPH and FRAP tests for antioxidant activity evaluation of the more potent compounds. Compound 26 proved, among the others, to be a good radical-scavenger and was also endowed with broad-spectrum UVA filtering capabilities, suitable to be developed as a protective molecule.
| Titolo: | A multitarget approach toward the development of a novel series of 8-substituted purines for photoprotection and prevention of ultra violet (UV) related damages |
| Autori: | BALDISSEROTTO, Anna (Ultimo) |
| Data di pubblicazione: | 2017 |
| Rivista: | |
| Handle: | http://hdl.handle.net/11392/2368271 |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Manuscript pre print.pdf | versione preprint | Pre-print | PUBBLICO - Pubblico con Copyright | Open Access Visualizza/Apri |
| Editoriale11392_2368271.pdf | versione editoriale | Full text (versione editoriale) | NON PUBBLICO - Accesso privato/ristretto | Administrator Richiedi una copia |
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