Plasma homocysteine (Hcy) has been recognized as cardiovascular fisk factor (CVRF) in the general population. Its role as either independent CVRF or its role in influencing others parameters is still matter of debate. We have evaluated the effect of duration of the disease and metabolic control in influencing Hcy levels in a group of type 2 diabetic subjects without renal impairment, determining and Its role as independent CVRF in this population. We measured fasting plasma glucose, HbA1c, blood pressure values, and Hcy in 208 type 2 diabetic subjects aging from 41 to 88 years, with a wide range of disease duration (0-41 yrs). Mean fasting plasma glucose was 148±54 mg/dl and HbA1c 8.3±2.0%. Mean blood pressure values were 143±18 over 87±8 mmHg. In type 2 diabetic subjects we observed a highly significant relationship with both duration of disease (p=O.ooo, r=0.68) and HbA1 c (p=O.OOO, r=0.64). After adjustment for age, BMI, duration of disease, blood pressure values, levels of HbA1c, vitamine-B12 and folate, mean Hcy level was still significantly higher in type 2 diabetic subjects with CHD versus those without CHD (12.0±3.1 mmol/I vs 10.2±2.8, p=O,03). In a stepwise multiple regression analyses including gender, age, smoking habits, systolic blood pressure, HbA1c, duration of disease, family history for CHD, Hcy level resulted as independent fiskfactor for CHD (R' =0.33, p=0.02). In a logistic regression analysis, Hcy resulted to be even predictive of CHD (p=0.03). Our observations show that although in type 2 diabetic patients Hcy is strictly influenced either by duralion of the disease and by Ihe degree of metabolic control, it still mantains a role as marker potentialily predictive of increased CVfisk.

Factors influencing plasma homocysteine as determinant of cardiovascular risk in type 2 diabetes mellitus

PASSARO, Angelina
Primo
;
FELLIN, Renato
Ultimo
1998

Abstract

Plasma homocysteine (Hcy) has been recognized as cardiovascular fisk factor (CVRF) in the general population. Its role as either independent CVRF or its role in influencing others parameters is still matter of debate. We have evaluated the effect of duration of the disease and metabolic control in influencing Hcy levels in a group of type 2 diabetic subjects without renal impairment, determining and Its role as independent CVRF in this population. We measured fasting plasma glucose, HbA1c, blood pressure values, and Hcy in 208 type 2 diabetic subjects aging from 41 to 88 years, with a wide range of disease duration (0-41 yrs). Mean fasting plasma glucose was 148±54 mg/dl and HbA1c 8.3±2.0%. Mean blood pressure values were 143±18 over 87±8 mmHg. In type 2 diabetic subjects we observed a highly significant relationship with both duration of disease (p=O.ooo, r=0.68) and HbA1 c (p=O.OOO, r=0.64). After adjustment for age, BMI, duration of disease, blood pressure values, levels of HbA1c, vitamine-B12 and folate, mean Hcy level was still significantly higher in type 2 diabetic subjects with CHD versus those without CHD (12.0±3.1 mmol/I vs 10.2±2.8, p=O,03). In a stepwise multiple regression analyses including gender, age, smoking habits, systolic blood pressure, HbA1c, duration of disease, family history for CHD, Hcy level resulted as independent fiskfactor for CHD (R' =0.33, p=0.02). In a logistic regression analysis, Hcy resulted to be even predictive of CHD (p=0.03). Our observations show that although in type 2 diabetic patients Hcy is strictly influenced either by duralion of the disease and by Ihe degree of metabolic control, it still mantains a role as marker potentialily predictive of increased CVfisk.
1998
Homocysteine, cardiovascula risk, type 2 diabetes
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2367671
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