Studies aiming at corroborating the regulation and function of the cortical cholinergic input system that postulates two separate modes of cholinergic neurotransmission. First a tonic component of cholinergic activity (changes on the scale of minutes) modulates the gain of thalamic input processing via stimulation of alfa4beta2 receptors expressed by thalamic afferents. Second , cue evoked glutamatergic release from thalamic afferents generates phasic or transient (scale of seconds) increases in acetylcholine release via stimulation of ionotropic glutamatergic receptors.
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Titolo: | Regulation and function of the tonic component of cortical acetylcholine release. | |
Autori: | ||
Data di pubblicazione: | 2010 | |
Handle: | http://hdl.handle.net/11392/2367199 | |
ISBN: | 978-90-9025672-6 | |
Appare nelle tipologie: | 04.2 Contributi in atti di convegno (in Volume) |