Studies aiming at corroborating the regulation and function of the cortical cholinergic input system that postulates two separate modes of cholinergic neurotransmission. First a tonic component of cholinergic activity (changes on the scale of minutes) modulates the gain of thalamic input processing via stimulation of alfa4beta2 receptors expressed by thalamic afferents. Second , cue evoked glutamatergic release from thalamic afferents generates phasic or transient (scale of seconds) increases in acetylcholine release via stimulation of ionotropic glutamatergic receptors.
File in questo prodotto:
Non ci sono file associati a questo prodotto.