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EnglishA 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.
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| Data di pubblicazione: | 2003 | |
| Titolo: | Nitrendipine-induced subacute cutaneous lupus erythematosus | |
| Autori: | Marzano, Angelo V; Borghi, Alessandro; Mercogliano, Maurizio; Facchetti, Maura; Caputo, Ruggero | |
| Rivista: | EUROPEAN JOURNAL OF DERMATOLOGY | |
| Parole Chiave: | Antiphospholipid syndrome; Drug-induced subacute cutaneous lupus erythematosus; Nitrendipine | |
| Abstract in inglese: | A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed. | |
| Handle: | http://hdl.handle.net/11392/2367177 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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