A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.
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Titolo: | Nitrendipine-induced subacute cutaneous lupus erythematosus |
Autori: | |
Data di pubblicazione: | 2003 |
Rivista: | |
Handle: | http://hdl.handle.net/11392/2367177 |
Appare nelle tipologie: | 03.1 Articolo su rivista |