Epigenetic regulation of pro-inflammatory genes and direct regulation of CFTR protein expression by MicroRNA has been reported. The objectives of the project MicroRNA-CF are: identification of specific MicroRNAs and their most relevant mRNA targets in CF bronchial epithelial cells; study of changes of the gene expression and secretome profile of CF using PNAs targeting MicroRNAs; development and biological validation of novelPNA-based molecules interfering with MicroRNAs involved in inflammation; development of PNA-based antagomiRNAs for CFTR stabilization.
Titolo del progetto: MicroRNA Therapeutics in CF: Targeting CFTR and inflammation networks (MicroRNA-CF)
GAMBARI, Roberto
2016
Abstract
Epigenetic regulation of pro-inflammatory genes and direct regulation of CFTR protein expression by MicroRNA has been reported. The objectives of the project MicroRNA-CF are: identification of specific MicroRNAs and their most relevant mRNA targets in CF bronchial epithelial cells; study of changes of the gene expression and secretome profile of CF using PNAs targeting MicroRNAs; development and biological validation of novelPNA-based molecules interfering with MicroRNAs involved in inflammation; development of PNA-based antagomiRNAs for CFTR stabilization.File in questo prodotto:
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