The Piave drainage system is one of the widest of north-eastern Italy. Starting from its source in the north-eastern Dolomites it reaches the Venetian plain flowing into the Adriatic Sea north of the Venice lagoon. It thus represents one of the most important natural routes connecting the northern Adriatic coast to the inner Alps. During the last decades scholars and amateurs have surveyed this large territory looking for Mesolithic findings. A high number of Early and Late Mesolithic sites have thus been discovered, and a few have also been excavated, such as Mondeval de Sora in the Belluno Dolomites and the settlements of the Cansiglio Plateau in the Prealpine fringe. Recent researches focused on this impressive dataset which includes sites extending across a wide variety of natural morphologies and vegetal landscapes – from the Adriatic coast to the Alpine watershed – have allowed a preliminary diachronical reconstruction of the territorial settlement strategies to be carried out.