In conclusion, we feel that data obtained through a clinically-driven protocol in two different PD models (neurotoxic and etiologic) and animal species (mouse and rat), convey a solid proof-of-concept that NOP receptor antagonists protect/rescue DA neurons from PD-like neurodegeneration. Although more evidence needs to be collected to claim that endogenous N/OFQ contributes to DA cell loss also in human PD, NOP receptor antagonists hold promise as symptomatic and disease-modifying agents in PD therapy

Parkinson's disease: no NOP, new hope

ARCURI, Ludovico;MERCATELLI, Daniela;MORARI, Michele
2017

Abstract

In conclusion, we feel that data obtained through a clinically-driven protocol in two different PD models (neurotoxic and etiologic) and animal species (mouse and rat), convey a solid proof-of-concept that NOP receptor antagonists protect/rescue DA neurons from PD-like neurodegeneration. Although more evidence needs to be collected to claim that endogenous N/OFQ contributes to DA cell loss also in human PD, NOP receptor antagonists hold promise as symptomatic and disease-modifying agents in PD therapy
Arcuri, Ludovico; Mercatelli, Daniela; Morari, Michele
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/2364280
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact