Many short peptides selectively permeabilize the bacteria plasma membrane, leading to their lyses and death: they are therefore a source of antibacterial molecules and inspiration for novel and more selective drugs, which may have wider application in many other fields, as selective anticancer drugs. In this chapter, it is presented a new method to investigate the permeabilization properties of antimicrobial peptides under strict physiological conditions, employing the patch-clamp technique coupled to a fast perfusion system.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
Titolo: | Studying the mechanism of membrane permeabilization induced by antimicrobial peptides using patch-clamp techniques | |
Autori: | ||
Data di pubblicazione: | 2017 | |
Handle: | http://hdl.handle.net/11392/2363328 | |
ISBN: | 978-1-4939-6735-3 978-1-4939-6737-7 | |
Appare nelle tipologie: | 02.1 Contributo in volume (Capitolo, articolo) |