Tumor microenvironment resembles an inflammation site (1). Chronic/smouldering inflammation confers advantages for the progression of tumor, contributing to both tumor antigen-specific tolerance and generalized T lymphocyte dysfunction (2). We plan to define the contribution that a dysfunctional purinergic signalling may give to support the immunosuppressive milieu of the tumour microenvironment. In particular we aim at the: 1. Pharmacological, biochemical, molecular and functional characterization of purinergic receptors expressed by myeloidderived suppressor cells (MDSCs). 4. Investigate the interplay between extracellular ATP and MDSCs within tumor microenvironment. 5. Verify the role of extracellular ATP in cell-to-cell communication within tumour microenvironment. 6. Test the effect of P2X7 and CD73 blockers on tumor progression and metastasis formation. 7. Develop novel techniques for the in vivo imaging of extracellular ATP.
Ricerca Finalizzata Ministero della Salute/Finalized Research Ministry of Health (RF-2011-02348435, 480 000 euro) Titolo/Title Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of immunosuppression within tumour microenvironment.
DI VIRGILIO, Francesco
2014
Abstract
Tumor microenvironment resembles an inflammation site (1). Chronic/smouldering inflammation confers advantages for the progression of tumor, contributing to both tumor antigen-specific tolerance and generalized T lymphocyte dysfunction (2). We plan to define the contribution that a dysfunctional purinergic signalling may give to support the immunosuppressive milieu of the tumour microenvironment. In particular we aim at the: 1. Pharmacological, biochemical, molecular and functional characterization of purinergic receptors expressed by myeloidderived suppressor cells (MDSCs). 4. Investigate the interplay between extracellular ATP and MDSCs within tumor microenvironment. 5. Verify the role of extracellular ATP in cell-to-cell communication within tumour microenvironment. 6. Test the effect of P2X7 and CD73 blockers on tumor progression and metastasis formation. 7. Develop novel techniques for the in vivo imaging of extracellular ATP.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
