Background An increased ATP concentration is a typical biochemical feature of the tumor microenvironment (TME). Likewise, many malignant tumors overexpress plasma membrane receptors for extracellular ATP (P2Rs), and P2Rs play a role in cancer cell intravasation/extravasation and therefore in metastatic spreading. These observations highlight the importance of purinergic signalling in cancer research. A substantial breakthrough in the biochemistry and cell biology of extracellular ATP has been the generation of a bioluminescent probe allowing the in vivo real-time measurement of the extracellular ATP concentration. This probe, named plasma membrane luciferase (pmeLUC) has allowed to unequivocally demonstrate that the TME is a "high-ATP environment", and that ATP within this environment can be used by cancer cells to support their metabolic requirements. Among the P2Rs, P2X7R is mostly involved in cancer as: a) is upregulated in cancer cells; b) promotes growth; c) stimulates the Warburg effect; d) is necessary for metastatic spreading. In addition, P2X7R is intimately linked to the NLRP3 inflammasome.
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|Autori:||Francesco Di Virgilio|
|Titolo:||AIRC IG 18581: The P2X7 receptor: a key determinant of cellular metabolic energetics in cancer progression.|
|Data di pubblicazione:||2016|
|Appare nelle tipologie:||08.1 Coordinamento Prog.Ricerca Naz. ed Internaz.|