Delayed orthopedic joint prosthesis infections (DOJP-Is) due to staphylococci frequently result in prosthetic revision. Specific and noninvasive diagnostic tests are unavailable, and DOJP-Is are commonly diagnosed at advanced stages of disease. An enzyme-linked immunosorbent assay (ELISA) was developed to detect serum antibodies against staphylococcal slime polysaccharide antigens. Using a cutoff of 0.35 ELISA units, the test showed a specificity of 95.1% (95% confidence interval [CI], 85.4 to 98.7%) and a sensitivity of 89.7% (71.5 to 97.3%) on a sample of 90 individuals.
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Data di pubblicazione: | 2011 | |
Titolo: | Staphylococcal IgM ELISA for the detection of peri-prosthetic joint infections | |
Autori: | Artini M; Romanò C; Manzoli L; Scoarughi GL; Papa R; Meani E; Drago L; Selan L. | |
Rivista: | JOURNAL OF CLINICAL MICROBIOLOGY | |
Abstract in inglese: | Delayed orthopedic joint prosthesis infections (DOJP-Is) due to staphylococci frequently result in prosthetic revision. Specific and noninvasive diagnostic tests are unavailable, and DOJP-Is are commonly diagnosed at advanced stages of disease. An enzyme-linked immunosorbent assay (ELISA) was developed to detect serum antibodies against staphylococcal slime polysaccharide antigens. Using a cutoff of 0.35 ELISA units, the test showed a specificity of 95.1% (95% confidence interval [CI], 85.4 to 98.7%) and a sensitivity of 89.7% (71.5 to 97.3%) on a sample of 90 individuals. | |
Digital Object Identifier (DOI): | 10.1128/JCM.01836-10 | |
Handle: | http://hdl.handle.net/11392/2361190 | |
Appare nelle tipologie: | 03.1 Articolo su rivista |