Staphylococcal IgM ELISA for the detection of peri-prosthetic joint infections

Delayed orthopedic joint prosthesis infections (DOJP-Is) due to staphylococci frequently result in prosthetic revision. Specific and noninvasive diagnostic tests are unavailable, and DOJP-Is are commonly diagnosed at advanced stages of disease. An enzyme-linked immunosorbent assay (ELISA) was developed to detect serum antibodies against staphylococcal slime polysaccharide antigens. Using a cutoff of 0.35 ELISA units, the test showed a specificity of 95.1% (95% confidence interval [CI], 85.4 to 98.7%) and a sensitivity of 89.7% (71.5 to 97.3%) on a sample of 90 individuals.

Data di pubblicazione: 2011
Titolo: Staphylococcal IgM ELISA for the detection of peri-prosthetic joint infections
Autori: Artini M; Romanò C; Manzoli L; Scoarughi GL; Papa R; Meani E; Drago L; Selan L.
Rivista: JOURNAL OF CLINICAL MICROBIOLOGY
Abstract in inglese: Delayed orthopedic joint prosthesis infections (DOJP-Is) due to staphylococci frequently result in prosthetic revision. Specific and noninvasive diagnostic tests are unavailable, and DOJP-Is are commonly diagnosed at advanced stages of disease. An enzyme-linked immunosorbent assay (ELISA) was developed to detect serum antibodies against staphylococcal slime polysaccharide antigens. Using a cutoff of 0.35 ELISA units, the test showed a specificity of 95.1% (95% confidence interval [CI], 85.4 to 98.7%) and a sensitivity of 89.7% (71.5 to 97.3%) on a sample of 90 individuals.
Digital Object Identifier (DOI): 10.1128/JCM.01836-10
Handle: http://hdl.handle.net/11392/2361190
Appare nelle tipologie:03.1 Articolo su rivista

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