Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection.

Hyperimmune globulins were reported to prevent and treat fetal CMV infection during pregnancy. Here we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titres and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to foetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging.

Data di pubblicazione: 2012
Titolo: Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection.
Autori: Polilli E; Parruti G; D'Arcangelo F; Tracanna E; Clerico L; Savini V; D'Antonio F; Rosati M; Manzoli L; D'Antonio D; Nigro G
Rivista: CLINICAL AND VACCINE IMMUNOLOGY
Abstract in inglese: Hyperimmune globulins were reported to prevent and treat fetal CMV infection during pregnancy. Here we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titres and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to foetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging.
Digital Object Identifier (DOI): 10.1128/CVI.00509-12
Handle: http://hdl.handle.net/11392/2361172
Appare nelle tipologie:03.1 Articolo su rivista

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