Purinergic signaling is involved in psoriasis, a chronic skin disease characterized by increased epidermis cell growth. In particular, Andrés et al. focus on the keratinocyte biology modulated by adenosine receptors providing evidence that the A2B subtype plays a prominent role in the reduction of keratinocyte proliferation whereas A2A and A2B agonists have antiinflammatory effects independent of adenosine receptors. The authors report that psoriatic epidermis presents a deregulated adenosine receptor expression profile with reduced A2B and increased A2A.
Purinergic signaling is involved in psoriasis, a chronic skin disease characterized by increased epidermis cell growth. In particular, Andres et al. focus on the keratinocyte biology modulated by adenosine receptors providing evidence that the A(2B) subtype plays a prominent role in the reduction of keratinocyte proliferation whereas A(2A) and A(2B) agonists have antiinflammatory effects independent of adenosine receptors. The authors report that psoriatic epidermis presents a deregulated adenosine receptor expression profile with reduced A(2B) and increased A(2A).
Deregulation of Adenosine Receptors in Psoriatic Epidermis: An Option for Therapeutic Treatment
MERIGHI, Stefania;BOREA, Pier Andrea;VARANI, Katia;GESSI, Stefania
2017
Abstract
Purinergic signaling is involved in psoriasis, a chronic skin disease characterized by increased epidermis cell growth. In particular, Andres et al. focus on the keratinocyte biology modulated by adenosine receptors providing evidence that the A(2B) subtype plays a prominent role in the reduction of keratinocyte proliferation whereas A(2A) and A(2B) agonists have antiinflammatory effects independent of adenosine receptors. The authors report that psoriatic epidermis presents a deregulated adenosine receptor expression profile with reduced A(2B) and increased A(2A).I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.