IDPN-induced changes in a variety of sensory, motor and autonomic nerves were studied by whole-mount immunocytochemistry. A full range of proximo-distal accumulations of neurofilament-like material was found, from paranuclear round bodies in perikarya to distal and preterminal axonal dilations. Conversely, both terminal areas and nodal-paranodal regions of myelinated axons showed striking, sharply localized loss of neurofilament-immunostaining. The latter change, when transport of neurofilaments is halted by IDPN, may indicate their local processing and/or differential transport at nodal-paranodal regions.

Experimental beta beta'-iminodipropionitrile (IDPN) neuropathy: neurofilament profile of sensory, motor and autonomic nerves as seen by immunocytochemistry on whole-mount preparations

GAUDIO, Rosa Maria;
1994

Abstract

IDPN-induced changes in a variety of sensory, motor and autonomic nerves were studied by whole-mount immunocytochemistry. A full range of proximo-distal accumulations of neurofilament-like material was found, from paranuclear round bodies in perikarya to distal and preterminal axonal dilations. Conversely, both terminal areas and nodal-paranodal regions of myelinated axons showed striking, sharply localized loss of neurofilament-immunostaining. The latter change, when transport of neurofilaments is halted by IDPN, may indicate their local processing and/or differential transport at nodal-paranodal regions.
1994
Ferri, G. L; Cichi, A; Bastone, A; Gaudio, Rosa Maria; Frontali, N; Dahl, D.
File in questo prodotto:
File Dimensione Formato  
EXPERIMENTAL BB' IMINODIPROPINITRILE IDPN NEUROPATHY_NEUROFILAMENT PROFILE OF SENSORY MOTRO AND AUTONOMIC NERVES AS SEEN BY IMMUNOCYTOCHEMISTRY ON WHOLE MOUNT PREPARATIONS.pdf

solo gestori archivio

Descrizione: Full text editoriale
Tipologia: Full text (versione editoriale)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 925.35 kB
Formato Adobe PDF
925.35 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2357786
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
social impact