Androgenic anabolic steroids (AAS), nandrolone decanoate in particular, are used world-wide to increase athletic performance by building muscle mass and strength. Out of a pharmacological and therapeutic contest (hypogonadism, bust cancer, delayed puberty, renal failure, anemia, etc.), they are on the list of forbidden substances of the International Olympic Committee (IOC) and of International Sport Federations (IOC 2001). The mechanism of action of all AAS is similar to all other steroid hormones in that it binds to an intracellular protein, known as an androgen receptor, in target tissues to form an androgen receptor complex in the cell nucleus. This steroid-receptor complex binds to palindromic DNA sequences, and specifically, to hormone response elements (HRE). It initiates gene transcription and the consequent synthesis of mRNA from DNA in the cell nucleus, and synthesis of chaperone proteins.
An experimental study on rat hearts receiving i.m. Nandrolone decanoate.
NERI, Margherita
2009
Abstract
Androgenic anabolic steroids (AAS), nandrolone decanoate in particular, are used world-wide to increase athletic performance by building muscle mass and strength. Out of a pharmacological and therapeutic contest (hypogonadism, bust cancer, delayed puberty, renal failure, anemia, etc.), they are on the list of forbidden substances of the International Olympic Committee (IOC) and of International Sport Federations (IOC 2001). The mechanism of action of all AAS is similar to all other steroid hormones in that it binds to an intracellular protein, known as an androgen receptor, in target tissues to form an androgen receptor complex in the cell nucleus. This steroid-receptor complex binds to palindromic DNA sequences, and specifically, to hormone response elements (HRE). It initiates gene transcription and the consequent synthesis of mRNA from DNA in the cell nucleus, and synthesis of chaperone proteins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
