The ecto-5'-nucleotidase/CD73 enzyme plays a pivotal role in generating an adenosine-enriched immunosuppressed and pro-angiogenic niche supporting cancer development. The targeting of CD73 leads to reorganization of tumor microenvironment, shaping the phenotype of the infiltrating T cells. The development of CD73 monoclonal antibodies offers a promising new avenue for antineoplastic treatment.

Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment

FERRARI, Davide
Penultimo
;
2016

Abstract

The ecto-5'-nucleotidase/CD73 enzyme plays a pivotal role in generating an adenosine-enriched immunosuppressed and pro-angiogenic niche supporting cancer development. The targeting of CD73 leads to reorganization of tumor microenvironment, shaping the phenotype of the infiltrating T cells. The development of CD73 monoclonal antibodies offers a promising new avenue for antineoplastic treatment.
Antonioli, Luca; Blandizzi, Corrado; Malavasi, Fabio; Ferrari, Davide; Haskó, György
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2356948
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