Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application.

Valacchi, Giuseppe; Muresan, Ximena Maria; Sticozzi, Claudia; Belmonte, Giuseppe; Pecorelli, Alessandra; Cervellati, Franco; Demaude, J; Krol, Y; Oresajo, C.

doi:10.1016/j.jdermsci.2016.02.007

CINECA IRIS Institutional Research Information System

IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.

Because its critical location, the skin is the main target of environmental stressors such as ozone (O3). Although O3 does not penetrate the deeper layers of skin it is able to react readily with stratum corneum lipids [1]. The toxic effects of O3 on the uppermost layers, induced either directly by the oxidation of biomolecules or by driving the radical-dependent production of cytotoxic, non-radical species (aldehydes), have repercussions on deeper cellular layers, triggering a cascade of cellular stress and inflammatory responses that can lead to skin pathologies [2] and [3]. Furthermore, O3 is able to induce the depletion of cutaneous antioxidants [4]. Therefore, topical application of antioxidants could prevent pollution induces cutaneous damages. In our recent work, the use of topical antioxidant mixtures (MIXs) has proven an effective defensive approach against O3-induced oxidative damage in human keratinocytes [5]. In the present study, which is a methodological extension of the one recently published [5], we evaluated the ability of the three MIXs to prevent the noxious effects of O3 on a customized reconstructed human epidermis (RHE, Episkin), where sebum was applied to reproduce a model resembling “in vivo” expectations [6

Scheda prodotto non validato

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Titolo:	Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application.
Autori:	VALACCHI, Giuseppe MURESAN, XIMENA MARIA STICOZZI, Claudia BELMONTE, Giuseppe PECORELLI, Alessandra CERVELLATI, Franco Demaude, J Krol, Y Oresajo, C. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2016
Rivista:	JOURNAL OF DERMATOLOGICAL SCIENCE
Handle:	http://hdl.handle.net/11392/2356528
Appare nelle tipologie:	03.1 Articolo su rivista

File in questo prodotto:

Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.