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EnglishPurpose: Higher positive end-expiratory pressure might induce lung inflation and recruitment, yielding enhanced regional lung protection. We measured positive end-expiratory pressure-related lung volume changes by electrical impedance tomography and by the helium dilution technique. We also used electrical impedance tomography to assess the effects of positive end-expiratory pressure on regional determinants of ventilator-induced lung injury. Methods: A prospective randomized crossover study was performed on 20 intubated adult patients: 12 with acute hypoxemic respiratory failure and 8 with acute respiratory distress syndrome. Each patient underwent protective controlled ventilation at lower (7 [7, 8] cmH2O) and higher (12 [12, 13] cmH2O) positive end-expiratory pressures. At the end of each phase, we collected ventilation, helium dilution, and electrical impedance tomography data. Results: Positive end-expiratory pressure-induced changes in lung inflation and recruitment measured by electrical impedance tomography and helium dilution showed close correlations (R2Â =Â 0.78, pÂ
| Data di pubblicazione: | 2016 | |
| Titolo: | Bedside assessment of the effects of positive end-expiratory pressure on lung inflation and recruitment by the helium dilution technique and electrical impedance tomography | |
| Autori: | Mauri, Tommaso; Eronia, Nilde; Turrini, Cecilia; Battistini, Marta; Grasselli, Giacomo; Rona, Roberto; Volta, Carlo Alberto; Bellani, Giacomo; Pesenti, Antonio | |
| Rivista: | INTENSIVE CARE MEDICINE | |
| Keywords: | Acute respiratory distress syndrome; Electrical impedance; Lung volume measurements; Mechanical ventilation; Positive end-expiratory pressure; Ventilator-induced lung injury; Critical Care and Intensive Care Medicine | |
| Abstract in inglese: | Purpose: Higher positive end-expiratory pressure might induce lung inflation and recruitment, yielding enhanced regional lung protection. We measured positive end-expiratory pressure-related lung volume changes by electrical impedance tomography and by the helium dilution technique. We also used electrical impedance tomography to assess the effects of positive end-expiratory pressure on regional determinants of ventilator-induced lung injury. Methods: A prospective randomized crossover study was performed on 20 intubated adult patients: 12 with acute hypoxemic respiratory failure and 8 with acute respiratory distress syndrome. Each patient underwent protective controlled ventilation at lower (7 [7, 8] cmH2O) and higher (12 [12, 13] cmH2O) positive end-expiratory pressures. At the end of each phase, we collected ventilation, helium dilution, and electrical impedance tomography data. Results: Positive end-expiratory pressure-induced changes in lung inflation and recruitment measured by electrical impedance tomography and helium dilution showed close correlations (R2 = 0.78, p | |
| Digital Object Identifier (DOI): | 10.1007/s00134-016-4467-4 | |
| Handle: | http://hdl.handle.net/11392/2355961 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Mauri ICM 2016.pdf | editoriale | Full text (versione editoriale) |  | Open Access Visualizza/Apri |
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