CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishA Laue lens is an optical component composed of a set of crystals that produce a convergent beam exploiting X-ray diffraction in transmission geometry. Employment of a system formed by a properly designed Laue lens coupled with an X-ray unit to selectively irradiate tumours is proposed. A convergent beam leads to a depth dose profile with a pronounced peak at the focal depth, which may result in a high precision of the dose delivery. Using a custom-made Monte Carlo code and the GAMOS code, we carried out a design study to determine the geometry and the optimal features of the crystals composing the lens. As an application, a Laue lens capable of focusing a 80keV beam 50cm downstream of the lens has been designed. The lens is composed of an ensemble of Si crystals with curved diffracting planes. The lens produces a focal spot of 2mm enclosing 7.64 × 106 photons for an electron charge of 1mC impinging on the surface of the X-ray tube anode. The combination of these important figures of merit makes the proposed system suitable for irradiating both sub-cm and larger tumour masses efficiently. A dose of 2Gy can be delivered to a small tumour in a few seconds, sparing at the same time the surrounding tissues.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Data di pubblicazione: | 2016 | |
| Titolo: | Laue lens to focus an X-ray beam for radiation therapy | |
| Autori: | Paternò, Gianfranco; Marziani, Michele; Camattari, Riccardo; Bellucci, Valerio; Mazzolari, Andrea; Gambaccini, Mauro; Guidi, Vincenzo | |
| Rivista: | JOURNAL OF APPLIED CRYSTALLOGRAPHY | |
| Parole Chiave: | dose delivery; Laue lenses; radiation therapy; X-ray beams; Biochemistry, Genetics and Molecular Biology (all) | |
| Abstract in inglese: | A Laue lens is an optical component composed of a set of crystals that produce a convergent beam exploiting X-ray diffraction in transmission geometry. Employment of a system formed by a properly designed Laue lens coupled with an X-ray unit to selectively irradiate tumours is proposed. A convergent beam leads to a depth dose profile with a pronounced peak at the focal depth, which may result in a high precision of the dose delivery. Using a custom-made Monte Carlo code and the GAMOS code, we carried out a design study to determine the geometry and the optimal features of the crystals composing the lens. As an application, a Laue lens capable of focusing a 80keV beam 50cm downstream of the lens has been designed. The lens is composed of an ensemble of Si crystals with curved diffracting planes. The lens produces a focal spot of 2mm enclosing 7.64 × 106 photons for an electron charge of 1mC impinging on the surface of the X-ray tube anode. The combination of these important figures of merit makes the proposed system suitable for irradiating both sub-cm and larger tumour masses efficiently. A dose of 2Gy can be delivered to a small tumour in a few seconds, sparing at the same time the surrounding tissues. | |
| Digital Object Identifier (DOI): | 10.1107/S1600576716000716 | |
| Handle: | http://hdl.handle.net/11392/2355836 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
File in questo prodotto:
Copyright © 2022