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EnglishThis study describes the development and optimization of a method to encapsulate the potent and expensive cannabinoids drugs in nanostructured lipid carriers; namely, URB597, AM251 and rimonabant have been considered. NLC production by melt and ultrasonication protocol has been specifically designed to optimize nanoparticle recovery and drug encapsulation efficiency. Special care has been devoted to the modality of oil and water phase emulsification and the entire production has been studied and discussed. NLC recovery, morphology, dimensional distribution and encapsulation efficiency are presented.
| Data di pubblicazione: | 2016 | |
| Titolo: | Encapsulation of cannabinoid drugs in nanostructured lipid carriers | |
| Autori: | Esposito, Elisabetta; Drechsler, Markus; Cortesi, Rita; Nastruzzi, Claudio | |
| Rivista: | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | |
| Keywords: | Nanostructured lipid carriers, Cannabinoid drugs, Cryo-TEM, nanoparticles, rimonabant, delivery, receptor | |
| Abstract in inglese: | This study describes the development and optimization of a method to encapsulate the potent and expensive cannabinoids drugs in nanostructured lipid carriers; namely, URB597, AM251 and rimonabant have been considered. NLC production by melt and ultrasonication protocol has been specifically designed to optimize nanoparticle recovery and drug encapsulation efficiency. Special care has been devoted to the modality of oil and water phase emulsification and the entire production has been studied and discussed. NLC recovery, morphology, dimensional distribution and encapsulation efficiency are presented. | |
| Digital Object Identifier (DOI): | 10.1016/j.ejpb.2016.03.005 | |
| Handle: | http://hdl.handle.net/11392/2355421 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Encapsulation of cannabinoid drugs in nanostructured lipid carriers.pdf | versione editoriale | Full text (versione editoriale) | NON PUBBLICO - Accesso privato/ristretto | Administrator Richiedi una copia |
| 11392_2355421_preprint_Esposito_Elisabetta.pdf | versione preprint | Pre-print | PUBBLICO - Pubblico con Copyright | Open Access Visualizza/Apri |
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