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EnglishThe group of matrix metalloproteinases (MMPs), calcium- and zinc-dependent proteolytic enzymes, is responsible for extracellular protein degradation. Acting together, supported by intracellular processes they are able to digest any phys- iological extracellular protein. However, the biochemistry of extracellular matrix (ECM) is very complex, and prote- olytic enzymes located in this compartment exert numerous pleiotropic e ects beyond the characteristic for the degrada- tion of structural elements. erefore, MMPs are involved into several physiological and pathological processes
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| Data di pubblicazione: | 2016 | |
| Titolo: | Matrix Metalloproteinases as a Pleiotropic Biomarker in Medicine and Biology | |
| Autori: | Kurzepa, Jacek; El-Demerdash, Fatma M.; Castellazzi, Massimiliano | |
| Rivista: | DISEASE MARKERS | |
| Parole Chiave: | Matrix Metalloproteinases, biomarkers, medicine, biology | |
| Abstract in inglese: | The group of matrix metalloproteinases (MMPs), calcium- and zinc-dependent proteolytic enzymes, is responsible for extracellular protein degradation. Acting together, supported by intracellular processes they are able to digest any phys- iological extracellular protein. However, the biochemistry of extracellular matrix (ECM) is very complex, and prote- olytic enzymes located in this compartment exert numerous pleiotropic e ects beyond the characteristic for the degrada- tion of structural elements. erefore, MMPs are involved into several physiological and pathological processes | |
| Handle: | http://hdl.handle.net/11392/2355246 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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