We have previously demonstrated that multiple sclerosis (MS) patients with KIR2DL2 expression on Natural killer (NK) cells are more susceptible to herpes simplex virus 1 (HSV-1) infection. We explored cytokine expression by NK cells during HSV-1 infection in association with KIR2DL2 expression. MS KIR2DL2+ NK cells failed to control HSV-1 infection and secreted high levels of Th17 cytokines, while MS KIR2DL2- NK cells released Th1 cytokines, mainly IFN-gamma. Our data showed, for the first time, a peculiar Th17 cytokine secretion by MS KIR2DL2+ NK cells in the presence of HSV-1 infection, that could be implicated in MS pathogenesis.

KIR2DL2 inhibitory pathway enhances Th17 cytokine secretion by NK cells in response to herpesvirus infection in multiple sclerosis patients

RIZZO, Roberta;BORTOLOTTI, Daria;FAINARDI, Enrico;GENTILI, Valentina;BOLZANI, Silvia;BALDI, Eleonora;CASETTA, Ilaria;GRANIERI, Enrico Gavino Giuseppe;ROTOLA, Antonella;DI LUCA, Dario
2016

Abstract

We have previously demonstrated that multiple sclerosis (MS) patients with KIR2DL2 expression on Natural killer (NK) cells are more susceptible to herpes simplex virus 1 (HSV-1) infection. We explored cytokine expression by NK cells during HSV-1 infection in association with KIR2DL2 expression. MS KIR2DL2+ NK cells failed to control HSV-1 infection and secreted high levels of Th17 cytokines, while MS KIR2DL2- NK cells released Th1 cytokines, mainly IFN-gamma. Our data showed, for the first time, a peculiar Th17 cytokine secretion by MS KIR2DL2+ NK cells in the presence of HSV-1 infection, that could be implicated in MS pathogenesis.
Rizzo, Roberta; Bortolotti, Daria; Fainardi, Enrico; Gentili, Valentina; Bolzani, Silvia; Baldi, Eleonora; Casetta, Ilaria; Granieri, Enrico Gavino Giuseppe; Rotola, Antonella; Furlan, R; DI LUCA, Dario
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/2354254
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