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EnglishWe have previously demonstrated that multiple sclerosis (MS) patients with KIR2DL2 expression on Natural killer (NK) cells are more susceptible to herpes simplex virus 1 (HSV-1) infection. We explored cytokine expression by NK cells during HSV-1 infection in association with KIR2DL2 expression. MS KIR2DL2(+) NK cells failed to control HSV-1 infection and secreted high levels of Th17 cytokines, while MS KIR2DL2(-) NK cells released Th1 cytokines, mainly IFN-gamma. Our data showed, for the first time, a peculiar Th17 cytokine secretion by MS KIR2DL2(+) NK cells in the presence of HSV-1 infection, that could be implicated in MS pathogenesis.
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| Data di pubblicazione: | 2016 | |
| Titolo: | KIR2DL2 inhibitory pathway enhances Th17 cytokine secretion by NK cells in response to herpesvirus infection in multiple sclerosis patients | |
| Autori: | Rizzo, R; Bortolotti, D; Fainardi, E; Gentili, V; Bolzani, S; Baldi, E; Casetta, I; Granieri, E; Rotola, A; Furlan, R; Di Luca, D. | |
| Rivista: | JOURNAL OF NEUROIMMUNOLOGY | |
| Parole Chiave: | Herpesvirus; Host/pathogens interactions; Inhibitory receptor; NK cells; Th17 | |
| Abstract in inglese: | We have previously demonstrated that multiple sclerosis (MS) patients with KIR2DL2 expression on Natural killer (NK) cells are more susceptible to herpes simplex virus 1 (HSV-1) infection. We explored cytokine expression by NK cells during HSV-1 infection in association with KIR2DL2 expression. MS KIR2DL2(+) NK cells failed to control HSV-1 infection and secreted high levels of Th17 cytokines, while MS KIR2DL2(-) NK cells released Th1 cytokines, mainly IFN-gamma. Our data showed, for the first time, a peculiar Th17 cytokine secretion by MS KIR2DL2(+) NK cells in the presence of HSV-1 infection, that could be implicated in MS pathogenesis. | |
| Digital Object Identifier (DOI): | 10.1016/j.jneuroim.2016.03.007. | |
| Handle: | http://hdl.handle.net/11392/2354254 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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