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EnglishReaction of hydrated copper(ii) mefenamate in the presence of diverse N-donor ligands such as N,N,N′,N′-tetramethylethylenediamine (temed), ethylenediamine (en), β-picoline (β-pic) in a methanol:water mixture (4:1, v/v) yielded crystalline monomeric copper(ii) complexes [Cu(temed) (mefenamato)2], 1, [Cu(en)2(H2O)2](mefenamato)2, 2 and [Cu(β-pic)2(mefenamato)2]·H2O, 3. The newly synthesized complexes have been characterized by elemental analysis, spectroscopic methods (FT-IR, UV-Vis and EPR), thermogravimetric analyses and single-crystal X-ray structure determination in the case of complexes 2 and 3. The ground-state geometry optimization of complex 1 was performed by DFT calculations. In order to verify the complexes capability to get bound and possibly transported by the albumin towards their biological targets (cells and/or tissues), the interaction with bovine (BSA) and human serum albumin (HSA) was studied by fluorescence emission spectroscopy. The interaction of complexes 1-3 with calf-thymus DNA (CT DNA) was monitored by UV-Vis spectroscopy, cyclic voltammetry, viscosity measurements and via the ethidium bromide (EB) displacement from the EB-DNA conjugate performed by fluorescence emission spectroscopy, as a preliminary approach to evaluate their potential biological activity.
| Data di pubblicazione: | 2016 | |
| Titolo: | New copper(II) complexes of the anti-inflammatory drug mefenamic acid: A concerted study including synthesis, physicochemical characterization and their biological evaluation | |
| Autori: | Sharma, Raj Pal; Kumar, Santosh; Venugopalan, Paloth; Ferretti, Valeria; Tarushi, Alketa; Psomas, George; Witwicki, Maciej | |
| Rivista: | RSC ADVANCES | |
| Keywords: | Chemistry; Chemical Engineering; Cu(II) complexes; citotoxicity | |
| Abstract in inglese: | Reaction of hydrated copper(ii) mefenamate in the presence of diverse N-donor ligands such as N,N,N′,N′-tetramethylethylenediamine (temed), ethylenediamine (en), β-picoline (β-pic) in a methanol:water mixture (4:1, v/v) yielded crystalline monomeric copper(ii) complexes [Cu(temed) (mefenamato)2], 1, [Cu(en)2(H2O)2](mefenamato)2, 2 and [Cu(β-pic)2(mefenamato)2]·H2O, 3. The newly synthesized complexes have been characterized by elemental analysis, spectroscopic methods (FT-IR, UV-Vis and EPR), thermogravimetric analyses and single-crystal X-ray structure determination in the case of complexes 2 and 3. The ground-state geometry optimization of complex 1 was performed by DFT calculations. In order to verify the complexes capability to get bound and possibly transported by the albumin towards their biological targets (cells and/or tissues), the interaction with bovine (BSA) and human serum albumin (HSA) was studied by fluorescence emission spectroscopy. The interaction of complexes 1-3 with calf-thymus DNA (CT DNA) was monitored by UV-Vis spectroscopy, cyclic voltammetry, viscosity measurements and via the ethidium bromide (EB) displacement from the EB-DNA conjugate performed by fluorescence emission spectroscopy, as a preliminary approach to evaluate their potential biological activity. | |
| Digital Object Identifier (DOI): | 10.1039/c6ra14706b | |
| Handle: | http://hdl.handle.net/11392/2353924 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| C6RA14706B.AAM.pdf | post print | Post-print | PUBBLICO - Pubblico con Copyright | Open Access Visualizza/Apri |
| 11392-2353924_fulltext_Ferretti_Valeria.pdf | versione editoriale | Full text (versione editoriale) | NON PUBBLICO - Accesso privato/ristretto | Administrator Richiedi una copia |
| RSC.Ferretti.preprint.pdf | versione preprint | Pre-print | NON PUBBLICO - Accesso privato/ristretto | Administrator Richiedi una copia |
http://hdl.handle.net/11392/2353924
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