The term 'dyslipidemia includes a wide family of lipoprotein metabolic defects often related to cardiovascular diseases. Despite the complexity of lipid disorders, current guidelines indicate LDL-C as the single most important therapeutic target; however, other lipido-proteic parameters, such as the concentration of lipoprotein subfractions (e.g., small-dense LDL) or their functional capacity (e.g., HDL reverse cholesterol transport), may display direct pro- or anti-atherogenic properties. Traditional lipid profiles may therefore be inadequate in representing dyslipidemia complexity and may prove to be ineffective in estimating the overall patients risk in this context. We designed a research project attempting to provide a coherent framework integrating traditional lipid profiling and advanced diagnostics, to assess qualitative and functional lipoprotein features in relevant clinical conditions and to correlate them with preclinical atherosclerosis. © 2010 Future Medicine Ltd.

Advanced diagnostic support in lipidology project: Role for phenotypic and functional evaluation of lipoproteins in dyslipidemias

FELLIN, Renato;VIGNA, Giovanni Battista;
2010

Abstract

The term 'dyslipidemia includes a wide family of lipoprotein metabolic defects often related to cardiovascular diseases. Despite the complexity of lipid disorders, current guidelines indicate LDL-C as the single most important therapeutic target; however, other lipido-proteic parameters, such as the concentration of lipoprotein subfractions (e.g., small-dense LDL) or their functional capacity (e.g., HDL reverse cholesterol transport), may display direct pro- or anti-atherogenic properties. Traditional lipid profiles may therefore be inadequate in representing dyslipidemia complexity and may prove to be ineffective in estimating the overall patients risk in this context. We designed a research project attempting to provide a coherent framework integrating traditional lipid profiling and advanced diagnostics, to assess qualitative and functional lipoprotein features in relevant clinical conditions and to correlate them with preclinical atherosclerosis. © 2010 Future Medicine Ltd.
Ardigò, D.; Bernini, F.; Borghi, C.; Calandra, S.; Cicero, Afg; Favari, E.; Fellin, Renato; Franzini, L.; Vigna, Giovanni Battista; Zimetti, F.; Zavaroni, I.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2353768
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