Introduction: The aim of this study was to determine the effects of variations in thread shape on the axial pullout strength of orthodontic miniscrews. Methods: A total of 35 miniscrews, 7 of each design being considered, were tested by performing pullout tests on a synthetic bone support. We used self-tapping and self-drilling miniscrews having a diameter of 2 mm and a thread shaft length of 12 mm (the longest and the largest supplied by the manufacturer). A buttress reverse thread shape served as the control design and was tested against 4 experimental designs, each manufactured with a modification in thread shape while maintaining all other characteristics. The experimental groups had the following thread designs: buttress, 75° joint profile, rounded, and trapezoidal. Results: The control group with a buttress reverse thread shape had consistently higher pullout strength values than did the other designs. A statistically significant reduction in pullout force was found between the buttress reverse and the buttress thread miniscrews. Conclusions: Thread design influenced the resistance to pullout of the orthodontic miniscrews. The buttress reverse thread shape provided the greatest pullout strength. © 2012 by the American Association of Orthodontists.