Sights set on a cure: Memoquin (1) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity. In animal models, 1 causes a remarkable decrease in the formation of AD neurodegenerative hallmarks and a significant reversal of behavioral deficits. hAChE, BACE-1, and NQO1 are enzymes targeted by 1.

A small molecule targeting the multifactorial nature of Alzheimer's disease

CAPSONI, Simona;
2007

Abstract

Sights set on a cure: Memoquin (1) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity. In animal models, 1 causes a remarkable decrease in the formation of AD neurodegenerative hallmarks and a significant reversal of behavioral deficits. hAChE, BACE-1, and NQO1 are enzymes targeted by 1.
2007
Cavalli, A; Bolognesi, Ml; Capsoni, Simona; Andrisano, V; Bartolini, M; Margotti, E; Cattaneo, A; Recanatini, M; Melchiorre, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2349941
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