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EnglishWe have characterized and quantified endothelin receptors in rat brain (anterior cerebral) and peripheral (aorta, carotid, and caudal) arteries, with the use of [I-125]endothelin and quantitative autoradiography. Endothelin binding was saturable, of high affinity, and totally displaced by the selective endothelin ET(A) antagonist BQ 123. A single class of ET(A) receptors is located in the medial layer of peripheral and cerebral arteries, and its quantification by autoradiography allows study of their regulation and function.
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| Data di pubblicazione: | 1995 | |
| Titolo: | Characterization of endothelin(A) receptors in cerebral and peripheral arteries of rat | |
| Autori: | DE OLIVEIRA AM; VISWANATHAN M; CAPSONI S; HEEMSKERK FMJ; CORREA FMA; SAAVEDRA JM | |
| Rivista: | PEPTIDES | |
| Abstract in inglese: | We have characterized and quantified endothelin receptors in rat brain (anterior cerebral) and peripheral (aorta, carotid, and caudal) arteries, with the use of [I-125]endothelin and quantitative autoradiography. Endothelin binding was saturable, of high affinity, and totally displaced by the selective endothelin ET(A) antagonist BQ 123. A single class of ET(A) receptors is located in the medial layer of peripheral and cerebral arteries, and its quantification by autoradiography allows study of their regulation and function. | |
| Handle: | http://hdl.handle.net/11392/2349910 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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