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EnglishPhenotypic knockout of nerve growth factor (NGF) activity in transgenic anti-NGF mice (AD11 mice) results in a progressive neurodegenerative phenotype resembling Alzheimer's disease. In this article, we examine whether and how the progressive neurodegenerative phenotype of AD11 mice could be prevented or ameliorated by pharmacological treatments with NGF or the cholinergic agonist galantamine, at a relatively early phase of Alzheimer's disease-like neurodegeneration. We demonstrate that the neurodegeneration induced by the expression of anti-NGF antibodies in AD11 mice can be largely reversed by NGF delivery through an olfactory route.
| Data di pubblicazione: | 2002 | |
| Titolo: | Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice | |
| Autori: | Capsoni, Simona; Giannotta, S; Cattaneo, A. | |
| Rivista: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | |
| Keywords: | NGF, nicotinic acetylcholine receptors, Alzheimer disease, messenger RNA, retrograde transport, cholinergic neurons, spatial memory, brain, neurotrophin | |
| Abstract in inglese: | Phenotypic knockout of nerve growth factor (NGF) activity in transgenic anti-NGF mice (AD11 mice) results in a progressive neurodegenerative phenotype resembling Alzheimer's disease. In this article, we examine whether and how the progressive neurodegenerative phenotype of AD11 mice could be prevented or ameliorated by pharmacological treatments with NGF or the cholinergic agonist galantamine, at a relatively early phase of Alzheimer's disease-like neurodegeneration. We demonstrate that the neurodegeneration induced by the expression of anti-NGF antibodies in AD11 mice can be largely reversed by NGF delivery through an olfactory route. | |
| Digital Object Identifier (DOI): | 10.1073/pnas.192442999 | |
| Handle: | http://hdl.handle.net/11392/2349853 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Capsoni et al., PNAS 2002, 99, 12432.pdf | versione editoriale | Full text (versione editoriale) | PUBBLICO - Pubblico con Copyright | Open Access Visualizza/Apri |
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