Export | Download | Add to List | More... Dialogues in Cardiovascular Medicine Volume 20, Issue 2, 2015, Pages 107-118 What role does intracellular and intercellular signaling play in cardiac remodeling? (Article) Rizzo, P.a , Ameri, P.b a Department of Morphology, Surgery, and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy b Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy View references (99) Abstract Pathological cardiac remodeling leads to progressive worsening of cardiac function and heart failure. Novel and more effective therapeutic strategies are needed to slow down or reverse this often fatal process. The dissection of the molecular events underlying cardiac remodeling could lead to the identification of promising new candidates for targeted treatment of heart failure. In this review, we discuss the role of the Notch and Akt (protein kinase B) signaling pathways in mediating intercellular and intracellular events that play an important role in the myocardium under physiological and pathological conditions, including remodeling.
What role does intracellular and intercellular signaling play in cardiac remodeling?
RIZZO, Paola;
2015
Abstract
Export | Download | Add to List | More... Dialogues in Cardiovascular Medicine Volume 20, Issue 2, 2015, Pages 107-118 What role does intracellular and intercellular signaling play in cardiac remodeling? (Article) Rizzo, P.a , Ameri, P.b a Department of Morphology, Surgery, and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy b Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy View references (99) Abstract Pathological cardiac remodeling leads to progressive worsening of cardiac function and heart failure. Novel and more effective therapeutic strategies are needed to slow down or reverse this often fatal process. The dissection of the molecular events underlying cardiac remodeling could lead to the identification of promising new candidates for targeted treatment of heart failure. In this review, we discuss the role of the Notch and Akt (protein kinase B) signaling pathways in mediating intercellular and intracellular events that play an important role in the myocardium under physiological and pathological conditions, including remodeling.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
