A large body of experimental and postmortem findings indicate that Alzheimer's disease (AD) is associated with increased oxidative stress (OxS) levels in the brain. Despite the current limitations of OxS assessment in living subjects, recent data suggest that oxidative challenge might increase early both in the central nervous system and peripheral fluids. The aim of this review was to provide an overview of the existing literature linking systemic OxS to brain OxS in AD. We firmly believe that continued research aimed at overcoming the methodological and design issues affecting the body of studies in this field is mandatory for successful development of an effective antioxidant-based treatment of AD.

Oxidative challenge in Alzheimer's disease: state of knowledge and future needs

CERVELLATI, Carlo
Primo
;
ROMANI, Arianna;VALACCHI, Giuseppe;SQUERZANTI, Monica;Sanz, Juana Maria;Ortolani, Beatrice
Penultimo
;
ZULIANI, Giovanni
Ultimo
2016

Abstract

A large body of experimental and postmortem findings indicate that Alzheimer's disease (AD) is associated with increased oxidative stress (OxS) levels in the brain. Despite the current limitations of OxS assessment in living subjects, recent data suggest that oxidative challenge might increase early both in the central nervous system and peripheral fluids. The aim of this review was to provide an overview of the existing literature linking systemic OxS to brain OxS in AD. We firmly believe that continued research aimed at overcoming the methodological and design issues affecting the body of studies in this field is mandatory for successful development of an effective antioxidant-based treatment of AD.
2016
Cervellati, Carlo; Wood, Paul L; Romani, Arianna; Valacchi, Giuseppe; Squerzanti, Monica; Sanz, Juana Maria; Ortolani, Beatrice; Zuliani, Giovanni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2340931
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