Based on our clinical observation and experimental results, it can be hypothesized that MgCl2 could act as an inhibitor of the Ca2+-extruding activity in keratinocytes favoring intracellular Ca2+-disponibility and Ca2+-dependent mechanisms in desmosome assembly. This may represent the molecular basis of the treatment of Hailey-Hailey disease with MgCl2 solution.
Efficacy of magnesium chloride in the treatment of Hailey-Hailey disease: some further considerations
BORGHI, AlessandroCo-primo
;RIMESSI, AlessandroCo-primo
;MINGHETTI, Sara;CORAZZA, Monica;PINTON, PaoloUltimo
;VIRGILI, AnnaPenultimo
2016
Abstract
Based on our clinical observation and experimental results, it can be hypothesized that MgCl2 could act as an inhibitor of the Ca2+-extruding activity in keratinocytes favoring intracellular Ca2+-disponibility and Ca2+-dependent mechanisms in desmosome assembly. This may represent the molecular basis of the treatment of Hailey-Hailey disease with MgCl2 solution.File in questo prodotto:
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HHD some further considerations.pdf
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