A series of ruthenium(II) bis(2,2'-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL(-1)) and minimum bactericidal concentration (MBC, 25 μg mL(-1)) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL(-1) and MBC = 100 μg mL(-1)). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL(-1), MBC, >100 μg mL(-1)). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

GAMBARI, Roberto;
2014

Abstract

A series of ruthenium(II) bis(2,2'-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL(-1)) and minimum bactericidal concentration (MBC, 25 μg mL(-1)) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL(-1) and MBC = 100 μg mL(-1)). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL(-1), MBC, >100 μg mL(-1)). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.
2014
Lam, P. L; Lu, G. L.; Hon, K. M.; Lee, K. W.; Ho, C. L.; Wang, X.; Tang, J. C. O.; Lam, K. H.; Wong, R. S. M.; Kok, S. H. L.; Bian, Z. X.; Li, H.; Lee, K. K. H.; Gambari, Roberto; Chui, C. H.; Wong, W. Y.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2339009
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