In the framework of LARAMED (Laboratory of Radionuclides for Medicine) and APOTEMA (Accelerator-driven Production Of Technetium and Molybdenum for medical Applications) projects, the development of a β-spectrometer started in 2012. In order to evaluate the radionuclidic and isotopic purities of accelerator-produced 99mTc (half-life about 6 h), the estimation of Tc-nuclides co-produced during irradiations is mandatory. Although the production of Tc-isotopes can be reduced as much as possible by using highly enriched 100Mo targets and by choosing an appropriate energy window for the incoming proton-beam, the production of the isomer 99gTc cannot be avoided, due to the peak of the 100Mo(p,2n)99gTc,99mTc reactions in the same energy range. 99gTc is a long half-life (2.111·105 y), pure β-emitter nuclide (End-point energy E=293.5 keV, I=99.9984%), also produced by decay of 99mTc and 99Mo (half-life about 66 h). The precise evaluation of 99gTc content in the final product is thus an essential task and for this reason a digital β-spectrometer based on the Triple to Dual Coincidence Ratio (TDCR) method was developed.
Development of a β-spectrometer Based on TDCR Method for 99gTc Activity Estimations
DI DOMENICO, Giovanni;PUPILLO, Gaia;SQUERZANTI, Stefano;SCARPELLI, Andrea;BOSCHI, Alessandra;PASQUALI, Micol;UCCELLI, Licia;MARTINI, Petra;TAIBI, Angelo;GAMBACCINI, Mauro;
2015
Abstract
In the framework of LARAMED (Laboratory of Radionuclides for Medicine) and APOTEMA (Accelerator-driven Production Of Technetium and Molybdenum for medical Applications) projects, the development of a β-spectrometer started in 2012. In order to evaluate the radionuclidic and isotopic purities of accelerator-produced 99mTc (half-life about 6 h), the estimation of Tc-nuclides co-produced during irradiations is mandatory. Although the production of Tc-isotopes can be reduced as much as possible by using highly enriched 100Mo targets and by choosing an appropriate energy window for the incoming proton-beam, the production of the isomer 99gTc cannot be avoided, due to the peak of the 100Mo(p,2n)99gTc,99mTc reactions in the same energy range. 99gTc is a long half-life (2.111·105 y), pure β-emitter nuclide (End-point energy E=293.5 keV, I=99.9984%), also produced by decay of 99mTc and 99Mo (half-life about 66 h). The precise evaluation of 99gTc content in the final product is thus an essential task and for this reason a digital β-spectrometer based on the Triple to Dual Coincidence Ratio (TDCR) method was developed.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
