First Accelerator-Based 99mTc GBq Production Levels and in-vivo Imaging Tests
for APOTEMA Experiment

Martini, Petra; Pupillo, Gaia; Boschi, Alessandra; Uccelli, Licia; Pasquali, Micol; Duatti, Adriano; DI DOMENICO, Giovanni; Salvini, A.; Strada, L.; Giganti, Melchiore; Taibi, Angelo; Gambaccini, Mauro; Prata, M.; Manenti, Simone; Groppi, F.; Loriggiola, M.; Cicoria, G.; Marengo, M.; Lucconi, G.; Bello, M.; Uzunov, N.

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The INFN CSN5 funded research project APOTEMA (Accelerator-driven ProductiOn of Technetium/Molybdenum for medical Applications) started in Italy since 2012, just after the Technetium-99m shortening occurred on 2009-2010. The feasibility of 99mTc production via the 100Mo(p,2n)99mTc direct reaction route was investigated in all the basic aspects, starting from the nuclear physics first (both theory and experimental activities). Then passing to the chemical issues involved (assessment of the best 99mTc separation extraction methods), up to the necessary design and development of a fully-automated, remote-controlled and operated module for the 99mTc extraction and separation, at GBq quantities. In this work the first Italian in vivo multimodality imaging studies (SPECT-CT) performed by using the generator- and accelerator-produced 99mTc pertechnetate and the labelled radiopharmaceuticals (RF) HMPAO (CERETC) and tetrofosmine (MYOVIEW) are here shortly discussed.

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Titolo:	First Accelerator-Based 99mTc GBq Production Levels and in-vivo Imaging Tests for APOTEMA Experiment
Autori:	MARTINI, Petra PUPILLO, Gaia BOSCHI, Alessandra UCCELLI, Licia PASQUALI, Micol DUATTI, Adriano DI DOMENICO, Giovanni Salvini, A. Strada, L. GIGANTI, Melchiore TAIBI, Angelo GAMBACCINI, Mauro Prata, M. Manenti, Simone Groppi, F. Loriggiola, M. Cicoria, G. Marengo, M. Lucconi, G. Bello, M. Uzunov, N. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2015
Abstract:	The INFN CSN5 funded research project APOTEMA (Accelerator-driven ProductiOn of Technetium/Molybdenum for medical Applications) started in Italy since 2012, just after the Technetium-99m shortening occurred on 2009-2010. The feasibility of 99mTc production via the 100Mo(p,2n)99mTc direct reaction route was investigated in all the basic aspects, starting from the nuclear physics first (both theory and experimental activities). Then passing to the chemical issues involved (assessment of the best 99mTc separation extraction methods), up to the necessary design and development of a fully-automated, remote-controlled and operated module for the 99mTc extraction and separation, at GBq quantities. In this work the first Italian in vivo multimodality imaging studies (SPECT-CT) performed by using the generator- and accelerator-produced 99mTc pertechnetate and the labelled radiopharmaceuticals (RF) HMPAO (CERETC) and tetrofosmine (MYOVIEW) are here shortly discussed.
Handle:	http://hdl.handle.net/11392/2338910
Appare nelle tipologie:	02.1 Contributo in volume (Capitolo, articolo)

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