The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intracellular zones are emerging as pivotal sites for the activities of several proapoptotic and antiapoptotic factors. Here, we review the function of the endoplasmic reticulum- mitochondria interface as a primary platform for decoding danger signals as well as a structural accommodation for several regulator or effector proteins.
Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes
MARCHI, Saverio;GIORGI, Carlotta;PINTON, Paolo
2014
Abstract
The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intracellular zones are emerging as pivotal sites for the activities of several proapoptotic and antiapoptotic factors. Here, we review the function of the endoplasmic reticulum- mitochondria interface as a primary platform for decoding danger signals as well as a structural accommodation for several regulator or effector proteins.File in questo prodotto:
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