The results of a numerical investigation of heat and fluid flow in a liquid cold plate for FM radio power amplifiers are presented. The objective is to verify, by using a commercial CFD code, the performance of a blister cold plate designed to dissipate the heat generated by a known set of electronic components, in order to limit their maximum temperature during operations. Since in a blister cold-plate mainly the cover is thermally active, the cold-plate is simplified and lightened by using plastics in the base plate. A 3-D conjugate CFD approach, where thermal and fluid flow analyses are combined, is followed. Several design options for the cold plate are examined and the validity of the full 3-D CFD approach in the dimensioning of the cooling systems of electronic equipment is demonstrated.